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1

Peptoid–Peptide Hybrids That Bind Syk SH2 Domains Involved in Signal Transduction

Rob Ruijtenbeek, John A. W. Kruijtzer, Wendy van de Wiel, Marcel J. E. Fischer, Martin Flück, Frank A. M. Redegeld, Rob M. J. Liskamp, Frans P. Nijkamp

Journal:

Year:

2001

Language:

english

File:

PDF, 141 KB

english, 2001

2

Cover Picture

Frank J. Dekker, Nico J. de Mol, Jeroen van Ameijde, Marcel J. E. Fischer, Rob Ruijtenbeek, Frank A. M. Redegeld, Rob M. J. Liskamp

Journal:

Year:

2002

Language:

english

File:

PDF, 20 KB

english, 2002

3

Replacement of the Intervening Amino Acid Sequence of a Syk-Binding Diphosphopeptide by a Nonpeptide Spacer with Preservation of High Affinity

Frank J. Dekker, Nico J. de Mol, Jeroen van Ameijde, Marcel J. E. Fischer, Rob Ruijtenbeek, Frank A. M. Redegeld, Rob M. J. Liskamp

Journal:

Year:

2002

Language:

english

File:

PDF, 150 KB

english, 2002

4

Multivalent Carbohydrate Recognition on a Glycodendrimer-Functionalized Flow-Through Chip

Hilbert M. Branderhorst, Rob Ruijtenbeek, Rob M. J. Liskamp, Roland J. Pieters

Journal:

Year:

2008

Language:

english

File:

PDF, 312 KB

english, 2008

5

Development of Selective Bisubstrate-Based Inhibitors Against Protein Kinase C (PKC) Isozymes By Using Dynamic Peptide Microarrays

Alex J. Poot, Jeroen van Ameijde, Monique Slijper, Adriënne van den Berg, Riet Hilhorst, Rob Ruijtenbeek, Dirk T. S. Rijkers, Rob M. J. Liskamp

Journal:

Year:

2009

Language:

english

File:

PDF, 438 KB

english, 2009

6

Rapid Screening of Lectins for Multivalency Effects with a Glycodendrimer Microarray

Núria Parera Pera, Hilbert M. Branderhorst, Raymond Kooij, Caroline Maierhofer, Marjolein van der Kaaden, Rob M. J. Liskamp, Valentin Wittmann, Rob Ruijtenbeek, Roland J. Pieters

Journal:

Year:

2010

Language:

english

File:

PDF, 482 KB

english, 2010

7

ChemInform Abstract: Replacement of the Intervening Amino Acid Sequence of a Syk-Binding Diphosphopeptide by a Nonpeptide Spacer with Preservation of High Affinity.

Frank J. Dekker, Nico J. de Mol, Jeroen van Ameijde, Marcel J. E. Fischer, Rob Ruijtenbeek, Frank A. M. Redegeld, Rob M. J. Liskamp

Journal:

Year:

2002

File:

PDF, 25 KB

2002

8

Characterization of a phosphorylated peptide and peptoid and peptoid–peptide hybrids by mass spectrometry

Rob Ruijtenbeek, Cees Versluis, Albert J. R. Heck, Frank A. M. Redegeld, Frans P. Nijkamp, Rob M. J. Liskamp

Journal:

Journal of Mass Spectrometry

Year:

2002

Language:

english

File:

PDF, 165 KB

english, 2002

9

Kinetic Analysis of the Mass Transport Limited Interaction between the Tyrosine Kinase lck SH2 Domain and a Phosphorylated Peptide Studied by a New Cuvette-Based Surface Plasmon Resonance Instrument

Nico J. de Mol, Emke Plomp, Marcel J.E. Fischer, Rob Ruijtenbeek

Journal:

Analytical Biochemistry

Year:

2000

Language:

english

File:

PDF, 140 KB

english, 2000

10

β-Glucuronyl carbamate based pro-moieties designed for prodrugs in ADEPT

Ruben G.G. Leenders, Kasper A.A. Gerrits, Rob Ruijtenbeek, Hans W. Scheeren, Hidde J. Haisma, Epie Boven

Journal:

Tetrahedron Letters

Year:

1995

Language:

english

File:

PDF, 234 KB

english, 1995

11

Peptide microarrays for detailed, high-throughput substrate identification, kinetic characterization, and inhibition studies on protein kinase A

Riet Hilhorst, Liesbeth Houkes, Adriënne van den Berg, Rob Ruijtenbeek

Journal:

Analytical Biochemistry

Year:

2009

Language:

english

File:

PDF, 553 KB

english, 2009

12

Kinomic Analysis Identifies Trk as a Target for Modulation of Radiation Sensitization in Vascular Endothelium

C.D. Willey, T. Tu, J. Jaboin, R. Ruijtenbeek, D.E. Hallahan

Journal:

International Journal of Radiation Oncology*Biology*Physics

Year:

2008

Language:

english

File:

PDF, 40 KB

english, 2008

13

Prediction of Response to Preoperative Chemoradiotherapy in Rectal Cancer by Multiplex Kinase Activity Profiling

Sigurd Folkvord, Kjersti Flatmark, Svein Dueland, Rik de Wijn, Krystyna Kotanska Grøholt, Knut H. Hole, Jahn M. Nesland, Rob Ruijtenbeek, Piet J. Boender, Marianne Johansen, Karl-Erik Giercksky, Anne

Journal:

International Journal of Radiation Oncology*Biology*Physics

Year:

2010

Language:

english

File:

PDF, 916 KB

english, 2010

14

Foetale programmering: consequenties op volwassen leeftijd

Karin Ruijtenbeek, J. G. R. De Mey, Carlos E. Blanco

Journal:

Tijdschrift voor Kindergeneeskunde

Year:

2001

File:

PDF, 81 KB

2001

15

Chronic moderate hypoxia during in ovo development alters arterial reactivity in chickens

K. Ruijtenbeek, C.G.A. Kessels, B.J.A. Janssen, N.J.J.E. Bitsch, G.E. Fazzi, G.M.J. Janssen, J. Mey, C.E. Blanco

Journal:

Pflügers Archiv European Journal of Physiology

Year:

2003

Language:

english

File:

PDF, 156 KB

english, 2003

16

Osteoblast-induced EGFR/ERBB2 signaling in androgen-sensitive prostate carcinoma cells characterized by multiplex kinase activity profiling

Åse Bratland, Piet J. Boender, Hanne K. Høifødt, Ingrid H. G. Østensen, Rob Ruijtenbeek, Meng-yu Wang, Jens P. Berg, Wolfgang Lilleby, Øystein Fodstad, Anne Hansen Ree

Journal:

Clinical and Experimental Metastasis

Year:

2009

Language:

english

File:

PDF, 441 KB

english, 2009

17

The platelet P2Y 12 receptor contributes to granule secretion through Ephrin A4 receptor

Tournoij, Erik, Koekman, C. Arnold, Du, Vivian X., Roest, Mark, Ruijtenbeek, Rob, Moll, Frans L., Akkerman, Jan-Willem N.

Journal:

Year:

2012

Language:

english

File:

PDF, 1.62 MB

english, 2012

18

Molecular toxicology and signal transduction pathways: Why not monitor directly!?

Riet Hilhorst, Rene Houtman, Rob Ruijtenbeek, Piet Boender, Michael McMillian, Peter Lord

Journal:

Year:

2011

Language:

english

File:

PDF, 94 KB

english, 2011

19

Kinomic profiling approach identifies Trk as a novel radiation modulator

John S. Jarboe, Jerry J. Jaboin, Joshua C. Anderson, Somaira Nowsheen, Jennifer A. Stanley, Faris Naji, Rob Ruijtenbeek, Tianxiang Tu, Dennis E. Hallahan, Eddy S. Yang, James A. Bonner, Christopher D.

Journal:

Radiotherapy and Oncology

Year:

2012

Language:

english

File:

PDF, 1.13 MB

english, 2012

20

1419 POSTER Identification of a Protein Kinase Activity Based Biomarker Fingerprint to Predict Response to Sunitinib, Sorafenib and Pazopanib in Scirrhous Gastric Cancer Cell Lines

Y. Koh, M. Serizawa, R. de Wijn, R. Hilhorst, T. Nakajima, H. Yasui, K. Yanagihara, M. Dankers, R. Ruijtenbeek, N. Boku

Journal:

European Journal of Cancer

Year:

2011

Language:

english

File:

PDF, 43 KB

english, 2011

21

Functional assay for shiga-like toxin via detection by antibody capture and multivalent galabiose binding

van Hattum, Hilde, van der Zwaluw, Kim, Visser, Gerben M., van Putten, Jos, Ruijtenbeek, Rob, Pieters, Roland J.

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2012

Language:

english

File:

PDF, 508 KB

english, 2012

22

Preparation of novel alkylated arginine derivatives suitable for click-cycloaddition chemistry and their incorporation into pseudosubstrate- and bisubstrate-based kinase inhibitors

van Ameijde, Jeroen, Poot, Alex J., van Wandelen, Loek T. M., Wammes, Angelique E. M., Ruijtenbeek, Rob, Rijkers, Dirk T. S., Liskamp, Rob M. J.

Journal:

Organic & Biomolecular Chemistry

Year:

2010

Language:

english

File:

PDF, 436 KB

english, 2010

23

Development of a microarray detection method for galectin cancer proteins based on ligand binding

van Hattum, Hilde, Martin, Nathaniel I., Ruijtenbeek, Rob, Pieters, Roland J.

Journal:

Analytical Biochemistry

Year:

2013

Language:

english

File:

PDF, 637 KB

english, 2013

24

Protein kinase activity profiling and identification of signalling pathways involved in Alzheimer's disease

Saskia M. Van Der Vies, Riet Hilhorst, Elise S. Van Haastert, Rob Ruijtenbeek, Philip Scheltens, Annemieke J.M. Rozemuller, Jeroen J.M. Hoozemans

Journal:

Alzheimer's & Dementia

Year:

2010

Language:

english

File:

PDF, 62 KB

english, 2010

25

Directed Modulation of Protein Kinase C Isozyme Selectivity with Bisubstrate-Based Inhibitors

van Wandelen, Loek T. M., van Ameijde, Jeroen, Mady, Ahmed S. A., Wammes, Angelique E. M., Bode, Alois, Poot, Alex J., Ruijtenbeek, Rob, Liskamp, Rob M. J.

Journal:

Year:

2012

Language:

english

File:

PDF, 500 KB

english, 2012

26

Inside Cover: Directed Modulation of Protein Kinase C Isozyme Selectivity with Bisubstrate-Based Inhibitors (ChemMedChem 12/2012)

van Wandelen, Loek T. M., van Ameijde, Jeroen, Mady, Ahmed S. A., Wammes, Angelique E. M., Bode, Alois, Poot, Alex J., Ruijtenbeek, Rob, Liskamp, Rob M. J.

Journal:

Year:

2012

File:

PDF, 999 KB

2012

27

PP96 Tumor tissue profiling at the drug targeting level: kinase activity

R. van Beuningen, R. Ruijtenbeek, L. Houkes, R. de Wijn, P. Boender, R. Hilhorst

Journal:

European Journal of Cancer Supplements

Year:

2009

Language:

english

File:

PDF, 55 KB

english, 2009

28

A versatile spectrophotometric protein tyrosine phosphatase assay based on 3-nitrophosphotyrosine containing substrates

van Ameijde, Jeroen, Overvoorde, John, Knapp, Stefan, den Hertog, Jeroen, Ruijtenbeek, Rob, Liskamp, Rob M.J.

Journal:

Analytical Biochemistry

Year:

2014

Language:

english

File:

PDF, 402 KB

english, 2014

29

Azide–alkyne cycloaddition affording enzymatically tunable bisubstrate based inhibitors of histone acetyltransferase PCAF

van Ameijde, Jeroen, Zwiebel, Addy P.R., Ruijtenbeek, Rob, Liskamp, Rob M.J.

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2014

Language:

english

File:

PDF, 523 KB

english, 2014

30

Cell-Penetrating Bisubstrate-Based Protein Kinase C Inhibitors

van Wandelen, Loek T. M., van Ameijde, Jeroen, Ismail-Ali, Ahmed F., van Ufford, H. C. (Linda) Quarles, Vijftigschild, Lodewijk A. W., Beekman, Jeffrey M., Martin, Nathaniel I., Ruijtenbeek, Rob, Lisk

Journal:

ACS Chemical Biology

Year:

2013

Language:

english

File:

PDF, 1.82 MB

english, 2013

31

The JH2 domain and SH2-JH2 linker regulate JAK2 activity: A detailed kinetic analysis of wild type and V617F mutant kinase domains

Sanz Sanz, Arturo, Niranjan, Yashavanthi, Hammarén, Henrik, Ungureanu, Daniela, Ruijtenbeek, Rob, Touw, Ivo P., Silvennoinen, Olli, Hilhorst, Riet

Journal:

Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics

Year:

2014

Language:

english

File:

PDF, 1.27 MB

english, 2014

32

Identification of new possible targets for leukemia treatment by kinase activity profiling

Ter Elst, Arja, Diks, Sander H., Kampen, Kim R., Hoogerbrugge, Peter M., Ruijtenbeek, Rob, Boender, Piet J., Sikkema, Arend H., Scherpen, Frank J. G., Kamps, Willem A., Peppelenbosch, Maikel P., de Bo

Journal:

Leukemia and Lymphoma

Year:

2011

Language:

english

File:

PDF, 1.17 MB

english, 2011

33

Real-Time Monitoring of the Dephosphorylating Activity of Protein Tyrosine Phosphatases Using Microarrays with 3-Nitrophosphotyrosine Substrates

van Ameijde, Jeroen, Overvoorde, John, Knapp, Stefan, den Hertog, Jeroen, Ruijtenbeek, Rob, Liskamp, Rob M. J.

Journal:

Year:

2013

Language:

english

File:

PDF, 1.03 MB

english, 2013

34

Chronic Hypoxia Stimulates Periarterial Sympathetic Nerve Development in Chicken Embryo

Ruijtenbeek, K., le Noble, F. A. C., Janssen, G. M. J., Kessels, C. G. A., Fazzi, G. E., Blanco, C. E., De Mey, J. G. R.

Journal:

Year:

2000

Language:

english

File:

PDF, 469 KB

english, 2000

35

Serine-305 Phosphorylation Modulates Estrogen Receptor Alpha Binding to a Coregulator Peptide Array, with Potential Application in Predicting Responses to Tamoxifen

Houtman, R., de Leeuw, R., Rondaij, M., Melchers, D., Verwoerd, D., Ruijtenbeek, R., Martens, J. W. M., Neefjes, J., Michalides, R.

Journal:

Molecular Cancer Therapeutics

Year:

2012

Language:

english

File:

PDF, 1.38 MB

english, 2012

36

Kinome Profiling in Pediatric Brain Tumors as a New Approach for Target Discovery

Sikkema, A. H., Diks, S. H., den Dunnen, W. F.A., ter Elst, A., Scherpen, F. J.G., Hoving, E. W., Ruijtenbeek, R., Boender, P. J., de Wijn, R., Kamps, W. A., Peppelenbosch, M. P., de Bont, E. S.J.M.

Journal:

Cancer Research

Year:

2009

Language:

english

File:

PDF, 605 KB

english, 2009

37

Nuclear Receptor-Coregulator Interaction Profiling Identifies TRIP3 as a Novel Peroxisome Proliferator-activated Receptor Cofactor

Koppen, A., Houtman, R., Pijnenburg, D., Jeninga, E. H., Ruijtenbeek, R., Kalkhoven, E.

Journal:

Molecular & Cellular Proteomics

Year:

2009

Language:

english

File:

PDF, 1.26 MB

english, 2009

38

Endogenous Phosphotyrosine Signaling in Zebrafish Embryos

Lemeer, S., Ruijtenbeek, R., Pinkse, M. W. H., Jopling, C., Heck, A. J. R., den Hertog, J., Slijper, M.

Journal:

Molecular & Cellular Proteomics

Year:

2007

Language:

english

File:

PDF, 597 KB

english, 2007

39

Chronic Moderate Hypoxia and Protein Malnutrition Both Induce Growth Retardation, But Have Distinct Effects on Arterial Endothelium-Dependent Reactivity in the Chicken Embryo

Ruijtenbeek, Karin, Kessels, Lilian C G A, De Mey, Jo G R, Blanco, Carlos E

Journal:

Pediatric Research

Year:

2003

Language:

english

File:

PDF, 160 KB

english, 2003

40

Protein Kinase Activity Profiling of Postmortem Human Brain Tissue

Hoozemans, Jeroen J.M., Hilhorst, Riet, Ruijtenbeek, Rob, Rozemuller, Annemieke J.M., van der Vies, Saskia M.

Journal:

Neurodegenerative Diseases

Year:

2012

Language:

english

File:

PDF, 153 KB

english, 2012

41

117 Predicting clinical response based on ex vivo drug treatment in renal cell carcinoma using kinase activity profiling

Oosterwijk-Wakka, J., Ruijtenbeek, R., Houkes, L., Mulders, P., Oosterwijk, E.

Journal:

European Urology Supplements

Year:

2016

Language:

english

File:

PDF, 107 KB

english, 2016

42

IRAK-4 KINASE INHIBITION REDUCES PRO-INFLAMMATORY CYTOKINE SECRETION BUT HAS NO EFFECT ON THE UPTAKE OF AMYLOID BETA BY HUMAN GLIAL CELLS

van der Vies, Saskia M., van Haastert, Elise S., Mulder, Sandra, Nielsen, Henrietta M., Veerhuis, Rob, Ruijtenbeek, Rob, Rozemuller, Annemieke J.M., Hilhorst, Riet, Hoozemans, Jeroen J.M.

Journal:

Alzheimer's & Dementia

Year:

2014

Language:

english

File:

PDF, 49 KB

english, 2014

43

Halftime - An Ambitious Goal!

Ruijtenbeek, Richard, Buijs, Cees, Kolet, Flip, van Atten, Jelle, Stolwijk, Henny

Journal:

IABSE Symposium Report

Year:

2013

Language:

english

File:

PDF, 306 KB

english, 2013

44

UM Cure 2020 − A consortium of European experts in uveal melanoma to identify new therapies for patients with metastatic disease

Dhomen, N., Marais, R., Jager, M.J., Snaar-Jagalska,, Coupland, S., Romanowska-Dixon, B., Mione, M.C., Valente, A., Ryll, B., Ruijtenbeek, R., Prestat, A., Vinolo, E., Roman-Roman, S.

Journal:

European Journal of Cancer

Year:

2016

Language:

english

File:

PDF, 72 KB

english, 2016

45

The Chicken Embryo in Developmental Physiology of the Cardiovascular System: A Traditional Model with New Possibilities

Ruijtenbeek, K., De Mey, J. G. R., Blanco, C. E.

Journal:

American Journal of Physiology - Regulatory, Integrative and Comparative Physiology

Year:

2002

Language:

english

File:

PDF, 48 KB

english, 2002

46

Cetuximab prevents methotrexate-induced cytotoxicity i n vitro through epidermal growth factor dependent regulation of renal drug transporters

Caetano-Pinto, Pedro, Jamalpoor, Amer, Ham, Janneke, Goumenou, Anastasia, Mommersteeg, Monique, Pijnenburg, Dirk, Ruijtenbeek, Rob, Sánchez-Romero, Natalia, van Zelst, Bertrand, Heil, Sandra, Jansen,

Journal:

Molecular Pharmaceutics

Year:

2017

Language:

english

File:

PDF, 1.75 MB

english, 2017

47

Measuring O-GlcNAc cleavage by OGA and cell lysates on a peptide microarray

Sharif, Suhela, Shi, Jie, Mostafa, Bourakba, Ruijtenbeek, Rob, Pieters, Roland J.

Journal:

Analytical Biochemistry

Year:

2017

Language:

english

File:

PDF, 2.35 MB

english, 2017

48

Peptide Microarray Analysis of the Cross-talk Between O-GlcNAcylation and Tyrosine Phosphorylation

Shi, Jie, Tomašič, Tihomir, Sharif, Suhela, Brouwer, Arwin J., Anderluh, Marko, Ruijtenbeek, Rob, Pieters, Roland J.

Journal:

Year:

2017

Language:

english

File:

PDF, 973 KB

english, 2017

49

Combinatorial model organism strategy to predict developmental and reproductive toxicology (DART)

Rooseboom, M., Wildwater, M., Currie, R., Dirks, R.P., Kerkhof, E., Haar, J. Louter–van de, Maxwell, S., Pears, C., Pijnenburg, D., Racz, P., Ruijtenbeek, R., Smulders, C., Spaink, H., Warren, E., Wha

Journal:

Toxicology Letters

Year:

2017

Language:

english

File:

PDF, 60 KB

english, 2017

50

Multiparametric Assessment of the Effects of Tyrosine Kinase Inhibitors (TKIs) on the (Electro)physiology of Human Induced Pluripotent Stem Cell (hiPSC)-Derived Cardiomyocytes

de Korte, Tessa, Nacken, Peter, Pijnenburg, Dirk, Ruijtenbeek, Rob, Stevenhagen, Fleur, Wilbers, René, den Hartogh, Sabine, Groten, John, Braam, Stefan, Vlaming, Maria

Journal:

Journal of Pharmacological and Toxicological Methods

Year:

2017

Language:

english

File:

PDF, 69 KB

english, 2017

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